Domperidone is contraindicated in the following situations: Known hypersensitivity to domperidone or any of the excipients; Prolactin-releasing pituitary tumor (prolactinoma); When stimulation of the gastric motility could be harmful e.g. in patients with gastro-intestinal haemorrhage, mechanical obstruction or perforation; In patients with moderate or severe hepatic impairment; In patients who have known existing prolongation of cardiac conduction intervals, particularly QTc, patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure; Co-administration with QT-prolonging drugs; Co-administration with potent CYP3A4 inhibitors (regardless of their QT prolonging effects).
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